Differences in the heritability of craniofacial skeletal and dental characteristics between twin pairs with skeletal Class I and II malocclusions
박헌묵, 김필종, 성주헌, 송윤미, 김홍기, 김영호, 백승학,
소속 상세정보
박헌묵 ( Park Heon-Mook ) - Seoul National University School of Dentistry Department of Orthodontics
김필종 ( Kim Pil-Jong ) - Seoul National University School of Dentistry Biomedical Knowledge Engineering Laboratory
성주헌 ( Sung Joo-Hon ) - Seoul National University School of Public Health Department of Epidemiology
송윤미 ( Song Yun-Mi ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Family Medicine
김홍기 ( Kim Hong-Gee ) - Seoul National University School of Dentistry Biomedical Knowledge Engineering Laboratory
김영호 ( Kim Young-Ho ) - Ajou University School of Medicine Department of Orthodontics
백승학 ( Baek Seung-Hak ) - Seoul National University School of Dentistry Department of Orthodontics
Abstract
Objective: To investigate differences in the heritability of skeletodental characteristics between twin pairs with skeletal Class I and Class II malocclusions.
Methods: Forty Korean adult twin pairs were divided into Class I (C-I) group (0° ≤ angle between point A, nasion, and point B [ANB]) ≤ 4°; mean age, 40.7 years) and Class II (C-II) group (ANB > 4°; mean age, 43.0 years). Each group comprised 14 monozygotic and 6 dizygotic twin pairs. Thirty-three cephalometric variables were measured using lateral cephalograms and were categorized as the anteroposterior, vertical, dental, mandible, and cranial base characteristics. The ACE model was used to calculate heritability (A > 0.7, high heritability). Thereafter, principal component analysis (PCA) was performed.
Results: Twin pairs in C-I group exhibited high heritability values in the facial anteroposterior characteristics, inclination of the maxillary and mandibular incisors, mandibular body length, and cranial base angles. Twin pairs in C-II group showed high heritability values in vertical facial height, ramus height, effective mandibular length, and cranial base length. PCA extracted eight components with 88.3% in the C-I group and seven components with 91.0% cumulative explanation in the C-II group.
Conclusions: Differences in the heritability of skeletodental characteristics between twin pairs with skeletal Class I and II malocclusions might provide valuable information for growth prediction and treatment planning.
키워드
Heritability; Twins; ACE model; Principal component analysis
원문 및 링크아웃 정보
등재저널 정보